Depressive symptoms in Parkinson's disease are related to decreased hippocampus and amygdala volume.
Identifieur interne : 000272 ( Main/Exploration ); précédent : 000271; suivant : 000273Depressive symptoms in Parkinson's disease are related to decreased hippocampus and amygdala volume.
Auteurs : Tom J. Van Mierlo [Pays-Bas] ; Chin Chung ; Elisabeth M. Foncke ; Henk W. Berendse ; Odile A. Van Den HeuvelSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Amygdala (pathology), Depression (etiology), Depression (pathology), Depression (physiopathology), Depressive Disorder (etiology), Depressive Disorder (pathology), Depressive Disorder (physiopathology), Female, Hippocampus (pathology), Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Personality Inventory, Quality of Life.
- MESH :
- complications : Parkinson Disease.
- etiology : Depression, Depressive Disorder.
- pathology : Amygdala, Depression, Depressive Disorder, Hippocampus, Parkinson Disease.
- physiopathology : Depression, Depressive Disorder, Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Personality Inventory, Quality of Life.
Abstract
Depression and anxiety are common in Parkinson's disease (PD), and are among the non-motor symptoms that interfere with quality of life dramatically. Motor, cognitive, and affective features overlap in PD, hampering diagnosis. To shed more light on the contribution of structural brain changes to the presence of PD-related depressive symptoms, we conducted a Voxel-Based Morphometry (VBM) study. We hypothesized that depressive symptoms in PD are related to regional gray matter (GM) volume loss within the limbic circuit. We analyzed the T1-weigthed magnetic resonance imaging (MRI) images of 67 PD patients with a mean disease duration of 2.95 (±3.39) years. Scores on the Beck Depression Inventory (BDI) and GM probability maps were analyzed by regression analysis to study the association between GM volume and severity of depressive symptoms. Results are reported at both the uncorrected and the family-wise error (FWE) corrected level for multiple comparisons. The BDI scores correlated negatively with bilateral hippocampus and right amygdala volume and positively with the volume of the anterior cingulate cortex. These findings confirm the hypothesized involvement of the limbic circuit in PD-related depressive symptoms. We speculate that non-dopaminergic changes are essential in the pathophysiology of depressive symptoms in PD, because our findings suggest the involvement of extra-striatal brain regions.
DOI: 10.1002/mds.26112
PubMed: 25600157
Affiliations:
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Le document en format XML
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Van Mierlo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, VU University Medical Center (VUmc), Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, VU University Medical Center (VUmc), Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Chung, Chin" sort="Chung, Chin" uniqKey="Chung C" first="Chin" last="Chung">Chin Chung</name></author><author><name sortKey="Foncke, Elisabeth M" sort="Foncke, Elisabeth M" uniqKey="Foncke E" first="Elisabeth M" last="Foncke">Elisabeth M. Foncke</name></author><author><name sortKey="Berendse, Henk W" sort="Berendse, Henk W" uniqKey="Berendse H" first="Henk W" last="Berendse">Henk W. Berendse</name></author><author><name sortKey="Van Den Heuvel, Odile A" sort="Van Den Heuvel, Odile A" uniqKey="Van Den Heuvel O" first="Odile A" last="Van Den Heuvel">Odile A. 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Van Mierlo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, VU University Medical Center (VUmc), Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, VU University Medical Center (VUmc), Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Chung, Chin" sort="Chung, Chin" uniqKey="Chung C" first="Chin" last="Chung">Chin Chung</name></author><author><name sortKey="Foncke, Elisabeth M" sort="Foncke, Elisabeth M" uniqKey="Foncke E" first="Elisabeth M" last="Foncke">Elisabeth M. Foncke</name></author><author><name sortKey="Berendse, Henk W" sort="Berendse, Henk W" uniqKey="Berendse H" first="Henk W" last="Berendse">Henk W. Berendse</name></author><author><name sortKey="Van Den Heuvel, Odile A" sort="Van Den Heuvel, Odile A" uniqKey="Van Den Heuvel O" first="Odile A" last="Van Den Heuvel">Odile A. Van Den Heuvel</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Amygdala (pathology)</term><term>Depression (etiology)</term><term>Depression (pathology)</term><term>Depression (physiopathology)</term><term>Depressive Disorder (etiology)</term><term>Depressive Disorder (pathology)</term><term>Depressive Disorder (physiopathology)</term><term>Female</term><term>Hippocampus (pathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Personality Inventory</term><term>Quality of Life</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term><term>Depressive Disorder</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Amygdala</term><term>Depression</term><term>Depressive Disorder</term><term>Hippocampus</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Depression</term><term>Depressive Disorder</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Personality Inventory</term><term>Quality of Life</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Depression and anxiety are common in Parkinson's disease (PD), and are among the non-motor symptoms that interfere with quality of life dramatically. Motor, cognitive, and affective features overlap in PD, hampering diagnosis. To shed more light on the contribution of structural brain changes to the presence of PD-related depressive symptoms, we conducted a Voxel-Based Morphometry (VBM) study. We hypothesized that depressive symptoms in PD are related to regional gray matter (GM) volume loss within the limbic circuit. We analyzed the T1-weigthed magnetic resonance imaging (MRI) images of 67 PD patients with a mean disease duration of 2.95 (±3.39) years. Scores on the Beck Depression Inventory (BDI) and GM probability maps were analyzed by regression analysis to study the association between GM volume and severity of depressive symptoms. Results are reported at both the uncorrected and the family-wise error (FWE) corrected level for multiple comparisons. The BDI scores correlated negatively with bilateral hippocampus and right amygdala volume and positively with the volume of the anterior cingulate cortex. These findings confirm the hypothesized involvement of the limbic circuit in PD-related depressive symptoms. We speculate that non-dopaminergic changes are essential in the pathophysiology of depressive symptoms in PD, because our findings suggest the involvement of extra-striatal brain regions.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement></list><tree><noCountry><name sortKey="Berendse, Henk W" sort="Berendse, Henk W" uniqKey="Berendse H" first="Henk W" last="Berendse">Henk W. Berendse</name><name sortKey="Chung, Chin" sort="Chung, Chin" uniqKey="Chung C" first="Chin" last="Chung">Chin Chung</name><name sortKey="Foncke, Elisabeth M" sort="Foncke, Elisabeth M" uniqKey="Foncke E" first="Elisabeth M" last="Foncke">Elisabeth M. Foncke</name><name sortKey="Van Den Heuvel, Odile A" sort="Van Den Heuvel, Odile A" uniqKey="Van Den Heuvel O" first="Odile A" last="Van Den Heuvel">Odile A. Van Den Heuvel</name></noCountry><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Van Mierlo, Tom J" sort="Van Mierlo, Tom J" uniqKey="Van Mierlo T" first="Tom J" last="Van Mierlo">Tom J. Van Mierlo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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